Pedro scored a fantastic bicycle kick as Barcelona beat David Moyes’s Real Sociedad to keep the La Liga title race in their own hands.
Barca went five points clear, for two hours at least, with Real Madrid hosting Valencia at 19:00 BST.
After a frustrating first half, Neymar headed home Lionel Messi’s cross to give Barca the lead.
And substitute Pedro wrapped it up late on with a brilliant acrobatic effort from the penalty spot.
This round of La Liga games is the last before a suspension of football in Spain starts in an argument over television rights.
If a solution is found and the season can continue, Barcelona need only to win their final two games – against champions Atletico Madrid and Deportivo La Coruna.
However, a draw would let Real Madrid back into the race as the Spanish league goes down to head-to-head and not goal difference, and Real have that advantage over Barca, who have now kept seven consecutive clean sheets.
In the reverse meeting in January, Moyes led La Real to a famous winbut, with the club safely at mid-table, they had little to play for at the Nou Camp.
Barca boss Luis Enrique made changes with Tuesday’s Champions League semi-final second leg against Barcelona in mind, following their 3-0 first-leg success.
Xavi, Adriano, Marc Bartra and Rafinha all came in but they still dominated from the start with Geronimo Rulli denying a Messi header and Luis Suarez heading wide.
The Real keeper then denied Gerard Pique with a good save, with the defender putting the rebound wide with an overhead kick.
Barcelona kept up the pressure in the second half, and finally led when Real defender Mikel Gonzalez headed Messi’s right-wing cross towards Neymar, who converted from close range.
The game was sealed when Pedro, only on the pitch for three minutes, scored a stunning overhead kick as a deflection looped in the air to him.
Barca are chasing a treble, with a Copa del Rey final against Athletic Bilbao on Saturday, 30 May – subject to football remaining suspended in Spain.
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Source: BBC Sport