A recent scientific discovery has shown that Tideglusib, a drug developed for and trialled to treat Alzheimer’s disease happens to promote the natural tooth re-growth mechanism, allowing the tooth to repair cavities.<\/p>\n
This breakthrough suggests that dental fillings may soon be left in the ash heap of history.<\/p>\n
The discovery was captured in a press release copied the Ghana News Agency.<\/p>\n
Tideglusib works by stimulating stem cells in the pulp of teeth, the source of new dentine.<\/p>\n
[contextly_sidebar id=”APZRjkFoNBQWcKrDd3YYX4xBI6hP2qDj”]Dentine is the mineralized substance beneath tooth enamel that gets eaten away by tooth decay.<\/p>\n
Teeth can naturally regenerate dentine without assistance, but only under certain circumstances.<\/p>\n
The pulp must be exposed through infection (such as decay) or trauma to prompt the manufacture of dentine.<\/p>\n
But even then, the tooth can only re-grow a very thin layer naturally-not enough to repair cavities caused by decay, which are generally deep.<\/p>\n
Tideglusib according to the release changes this outcome because it turns off the GSK-3 enzyme, which stops dentine from forming.<\/p>\n
In the research, the team inserted small, biodegradable sponges made of collagen soaked in Tideglusib into cavities.<\/p>\n
The sponges triggered dentine growth and within six weeks, the damage was repaired.<\/p>\n
The collagen structure of the sponges melted away, leaving only the intact tooth.<\/p>\n
The release further noted that the procedure has only been used in mouse teeth.<\/p>\n
King\u2019s College London Dental Institute Professor and lead author Paul Sharpe had said \u201cUsing a drug that has already been tested in clinical trials for Alzheimer\u2019s disease provides a real opportunity to get this dental treatment quickly into clinics.\u201d<\/p>\n
He added that, \u201cThe simplicity of our approach makes it ideal as a clinical dental product for the natural treatment of large cavities, by providing both pulp protection and restoring dentine.\u201d<\/p>\n
The team suggested more work needed to be done on the finding.<\/p>\n
–<\/p>\n
Source: GNA<\/p>\n","protected":false},"excerpt":{"rendered":"
A recent scientific discovery has shown that Tideglusib, a drug developed for and trialled to treat Alzheimer’s disease happens to promote the natural tooth re-growth mechanism, allowing the tooth to repair cavities. This breakthrough suggests that dental fillings may soon be left in the ash heap of history. The discovery was captured in a press […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[19,11],"tags":[1841,1842,3,1843,1844],"yoast_head":"\n