This breakthrough suggests that dental fillings may soon be left in the ash heap of history.

The discovery was captured in a press release copied the Ghana News Agency.

Tideglusib works by stimulating stem cells in the pulp of teeth, the source of new dentine.

[contextly_sidebar id=”APZRjkFoNBQWcKrDd3YYX4xBI6hP2qDj”]Dentine is the mineralized substance beneath tooth enamel that gets eaten away by tooth decay.

Teeth can naturally regenerate dentine without assistance, but only under certain circumstances.

The pulp must be exposed through infection (such as decay) or trauma to prompt the manufacture of dentine.

But even then, the tooth can only re-grow a very thin layer naturally-not enough to repair cavities caused by decay, which are generally deep.

Tideglusib according to the release changes this outcome because it turns off the GSK-3 enzyme, which stops dentine from forming.

In the research, the team inserted small, biodegradable sponges made of collagen soaked in Tideglusib into cavities.

The sponges triggered dentine growth and within six weeks, the damage was repaired.

The collagen structure of the sponges melted away, leaving only the intact tooth.

The release further noted that the procedure has only been used in mouse teeth.

King’s College London Dental Institute Professor and lead author Paul Sharpe had said “Using a drug that has already been tested in clinical trials for Alzheimer’s disease provides a real opportunity to get this dental treatment quickly into clinics.”

He added that, “The simplicity of our approach makes it ideal as a clinical dental product for the natural treatment of large cavities, by providing both pulp protection and restoring dentine.”

The team suggested more work needed to be done on the finding.

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Source: GNA

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The 62-year-old Italian takes over from Fernando Santos, whose contract expired after the 2014 World Cup.

The Portuguese guided Greece to the last 16 in Brazil and Ranieri will now focus on qualification for Euro 2016.

The Greek Football Federation said: “The Italian coach is expected to lead our group to new successes with Euro 2016 on the horizon.”

Ranieri has managed at 14 different club sides – including Juventus, Roma and Inter Milan – but is yet to test himself on the international stage.

During four years at Chelsea, he improved the team’s Premier League points tally year on year and reached the semi-finals of the Champions League in 2004.

He was sacked a year after Roman Abramovich’s takeover of the club and was replaced by Jose Mourinho.

In his last post, Ranieri led Monaco to promotion to Ligue 1 and finished second on their return to the top flight in the 2013-14 season, before being sacked.

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Source: BBC Sport

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