A recent scientific discovery has shown that Tideglusib, a drug developed for and trialled to treat Alzheimer’s disease happens to promote the natural tooth re-growth mechanism, allowing the tooth to repair cavities.<\/p>\n
This breakthrough suggests that dental fillings may soon be left in the ash heap of history.<\/p>\n
The discovery was captured in a press release copied the Ghana News Agency.<\/p>\n
Tideglusib works by stimulating stem cells in the pulp of teeth, the source of new dentine.<\/p>\n
[contextly_sidebar id=”APZRjkFoNBQWcKrDd3YYX4xBI6hP2qDj”]Dentine is the mineralized substance beneath tooth enamel that gets eaten away by tooth decay.<\/p>\n
Teeth can naturally regenerate dentine without assistance, but only under certain circumstances.<\/p>\n
The pulp must be exposed through infection (such as decay) or trauma to prompt the manufacture of dentine.<\/p>\n
But even then, the tooth can only re-grow a very thin layer naturally-not enough to repair cavities caused by decay, which are generally deep.<\/p>\n
Tideglusib according to the release changes this outcome because it turns off the GSK-3 enzyme, which stops dentine from forming.<\/p>\n
In the research, the team inserted small, biodegradable sponges made of collagen soaked in Tideglusib into cavities.<\/p>\n
The sponges triggered dentine growth and within six weeks, the damage was repaired.<\/p>\n
The collagen structure of the sponges melted away, leaving only the intact tooth.<\/p>\n
The release further noted that the procedure has only been used in mouse teeth.<\/p>\n
King\u2019s College London Dental Institute Professor and lead author Paul Sharpe had said \u201cUsing a drug that has already been tested in clinical trials for Alzheimer\u2019s disease provides a real opportunity to get this dental treatment quickly into clinics.\u201d<\/p>\n
He added that, \u201cThe simplicity of our approach makes it ideal as a clinical dental product for the natural treatment of large cavities, by providing both pulp protection and restoring dentine.\u201d<\/p>\n
The team suggested more work needed to be done on the finding.<\/p>\n
–<\/p>\n
Source: GNA<\/p>\n","protected":false},"excerpt":{"rendered":"
A recent scientific discovery has shown that Tideglusib, a drug developed for and trialled to treat Alzheimer’s disease happens to promote the natural tooth re-growth mechanism, allowing the tooth to repair cavities. This breakthrough suggests that dental fillings may soon be left in the ash heap of history. The discovery was captured in a press […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"jnews_social_meta":[],"jnews_override_counter":[],"footnotes":""},"categories":[19,11],"tags":[1841,1842,3,1843,1844],"class_list":["post-366920","post","type-post","status-publish","format-standard","hentry","category-health","category-top-stories","tag-cavities","tag-drug-to-re-grow-tooth-and-seal-cavities","tag-ghana-news","tag-teeth","tag-tooth"],"_links":{"self":[{"href":"https:\/\/citifmonline.com\/index.php?rest_route=\/wp\/v2\/posts\/366920","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/citifmonline.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/citifmonline.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/citifmonline.com\/index.php?rest_route=\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/citifmonline.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=366920"}],"version-history":[{"count":0,"href":"https:\/\/citifmonline.com\/index.php?rest_route=\/wp\/v2\/posts\/366920\/revisions"}],"wp:attachment":[{"href":"https:\/\/citifmonline.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=366920"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/citifmonline.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=366920"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/citifmonline.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=366920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}